I found that things became much more pleasant on here when I blocked hexbear. I recently blocked lemmy.ml as well, but I may reverse that if I find that I’m missing too much good content.
I’m open to other ideas on how to mostly avoid people who love conflict or argue in bad faith.
I don’t know how to block a whole instance, but in reality I’ve only seen the communities that I’ve subscribed to and some other lame stuff… I’ve blocked all the shitty specific meme communities and web comics though. Call me a cynic.