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Naltrexone

I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.

  • Bye@lemmy.world
    18·
    1 year ago

    water

    • makes my headaches go away
    • makes it easier to poop
    • tastes good
    • cools me down on a hot day
    • super inexpensive, so cheap you can bathe in it
    • only bad part is that it makes you need to pee
    • inetknght@lemmy.ml
      31·
      1 year ago

      tastes good

      Sir, let’s discuss the taste of water.

      My sister tells me water is tasteless. I disagree. Water definitely has a taste. I have yet to find water with a taste I like except when I am very dehydrated.

      Tap water? Definitely no. Filtered water? Nope. Mineral water? Nah. Flavored water? Eugh.

      Tea, though. Tea is amazing. Especially coffee tea. Coffee tea is amazing. You take coffee beans, grind them up, and pass hot water through it. It’s so amazing.

      • accideath@lemmy.world
        5·
        1 year ago

        Not every tap water tastes the same. I have had tap water that is a bliss to drink but I’ve also had tap water that was barely drinkable without being filtered…

        Also, tea and coffee also profit from using good water while making them.

      • Bye@lemmy.world
        3·
        1 year ago

        No idea where you live, but the tap water is amazing where I live (somewhere in the western United States). And it comes from a set of glaciers that’s basically behind my house.

        If my tap water tasted bad I’d probably set up a solar still to purify it.

      • cheese_greater@lemmy.worldOP
        1·
        1 year ago

        You tried Fiji or Evian? I find them so damn refreshing and “palatable” even tho I am at baseline a HydrationHomie

  • Protoknuckles@lemmy.world
    8·
    1 year ago

    Metamucil (psyillium fibre)

    It’s kinda simple, but Metamucil. I would get terrible stomach aches, bloating and constipation whenever I had greasy food. Now, if I have 1-2 servings of Metamucil a day, then 1 extra right as I eat greasy food, I don’t feel terrible!

  • foggy@lemmy.world
    6·
    1 year ago

    Dramamine!!

    Oh, man.

    You ever wake up on a day you want to do nothing but sleep in, but you’re awake and you hate it?

    Take one, rip the bong, watch some bs and take a nap 😴

  • mrmule@lemmy.world
    71·
    1 year ago

    Omeprazole

    Got stomach bad acid? Want it go away for days or weeks on end without antacid? Omeprazole works like a dream and is available without prescription in most countries except Japan.

    • cheese_greater@lemmy.worldOP
      3·
      1 year ago

      You don’t, like, take that chronically do ya? I’ve heard that vigorously warned against…

      Thanks for bringing this up, I’m curious about folks’ experiences/thoughts regarding Proton Pump Inhibitors

      • mrmule@lemmy.world
        3·
        1 year ago

        I was warned not to use it chronically. I use it perhaps 2 days each month. You need to be aware of your triggers, such as fatty or spicey foods and alcohol. Also try and self diagnose stomach acid symptoms as early as possible.

        • cheese_greater@lemmy.worldOP
          1·
          1 year ago

          Ya that sounds better. I pop a Tums once in a blue moon but my diet is much cleaner to the effect I rarely need it anymore.

      • fjordbasa@lemmy.world
        3·
        1 year ago

        It may be prescribed long term if the benefits outweigh the possible risks. If someone is taking it in their own, it’s probably better to talk to their doc about it. My understanding is that it’s safe but can have long term effects and needs to be stepped down if you stop after taking it a while

            • cheese_greater@lemmy.worldOP
              2·
              1 year ago

              I mean in your case or is this all academic/hypothetical? I assumed you were describing your personal use case. Did your dr prescribe and refill it or was it specialist?

              • mrmule@lemmy.world
                4·
                1 year ago

                I was in Japan this year and I had run out of omeprazole, in JP you cannot buy it over the counter. Ofc cue a bad few days of acid and luckily there was a GI specialist near my hotel. He noted that I had used PPI before and gave me a prescription for 60 tablets

              • mrmule@lemmy.world
                2·
                1 year ago

                I did, from a specialist in Japan. It really helps me as I can get extreme symptoms such as nausia, vomiting, insane back pain and inability to eat anything. No other medicines have helped me like this.

  • cheese_greater@lemmy.worldOP
    71·
    1 year ago

    Naltrexone

    I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.

    • naevaTheRat@lemmy.dbzer0.com
      2·
      1 year ago

      How do you find it? I’ve been curious but it’s very expensive. I come from a long line of alcoholic suicides and have had issues with it. Not like permadrunk but 4-6 drinks each evening when it gets out of hand (I also homebrew quite delicious beer and wine which does not help but is fun and I don’t want to stop that :/).

      I enjoy a good beer or wine and would love to have a sustainable one bottle on the weekend type relationship with the drug again rather than cutting it out totally.

      • cheese_greater@lemmy.worldOP
        41·
        1 year ago

        Just talk to your dr and tell him you suspect you have AUD (alcohol use disorder) and you’d like to trial naltrexone (50mg+generic) to see if it helps you handle booze+moderation.

        Its called

        Sinclair protocol/method

        All it is and requires is:

        1. If you are going to drink, pop a naltrexone 50mg
        2. Set a timer and wait 90 minutes (==1.5 hrs)
        3. Once you’ve taken naltrexone and waited that 90 mins, YOU MUST HAVE AT LEAST 1 alcoholic beverage, don’t get hung up on how many.
        4. Count your drinks each time you have one and keep that data in an app or spreadsheet to track over time.

        Just show your doctor this reply to give them an idea

        Do not take no for an answer. You have a family history of alcohol-related pathology and let him know you’ll be drinking with/without their help as a last resort.

        • naevaTheRat@lemmy.dbzer0.com
          2·
          1 year ago

          I am in Australia, it’s not covered on the pharmaceutical benefits scheme so it’s something like 350 AUD a box.

          My ex tried it and it worked for him, but he was earning 3x what I do so it was more affordable.

          • cheese_greater@lemmy.worldOP
            21·
            1 year ago

            Edit: Also look into baclofen, per the book by a French doctor called End of My Addiction, I used it as an adjuvant to get me off initially to scratch the itch and safely replace but it is nowhere near as compelling as alcohol. I still keep it around for that and if I get a muscle spasm and I don’t want to sit in the hospital but I never use it unless I def need to. I hate the fuzziness and tearing up of my eyes it can cause at higher doses

            What about nalfamene, can you call ur version of NHS and submit an exceptional drug request form? Any Aussies wanna chime in regarding getting stuff covered?

            All you need is an opioid-antagonist, usually they will also be approved for alcoholism/AUD (same name as dollar ;), there must be a way to access it. If not, you could try breaking them i half to 25mg and see where that gets you. It may well work, there’s work being done on low-dose naltrexone at far lower doses that seem to still have variable efficacy relative to the treatment regime/profile so that might be a way to cut the price in half.

            Talk to your dr and ask how you can get access and if they can help facillitate that.

            • naevaTheRat@lemmy.dbzer0.com
              2·
              1 year ago

              It’s definitely prescribed. Doing some reading now and it seems like it might be now be authorisable with special authority if and only if you’re also doing “a comprehensive treatment program” so likely therapy etc which is probably more expensive than just eating the cost. A visit to the GP atm sets me back like 70 bucks, seems like generic naltrexone is about 150 now. Not a cheap thing to trial what with thr economy up the shitter now.

              I wonder if I can buy some clandestinely, I doubt you’d get in too much trouble if caught importing an opiate antagonist.

              p.s. so glad our healthcare system is collapsing in order to make a few old white guys extremely rich. Whenever I have to wait 3 months to see a doctor I comfort myself with the thought of Gerry Harvey wiping his arse with 100 dollar notes.

  • tsonfeir@lemm.ee
    5·
    1 year ago

    Propranolol

    It’s a blood pressure medication that acts pretty fast. They give it to people who experience anxiety. If you sometimes get overwhelmed or have anxiety, just pop one of these bad boys and in 30 minutes you’re calmed the fuck down and you can deal with it rationally. 

    • naevaTheRat@lemmy.dbzer0.com
      3·
      1 year ago

      N.B. Some people have a paradoxical reaction of becoming very depressed temporarily.

      Idk if it’s on the possible side effects yet but you can find discussions on forums etc going back decades. Very rare, and transient, but if trying for the first time something to be aware of as a risk.

    • feedum_sneedson@lemmy.world
      2·
      1 year ago

      I use nebivolol instead which is highly cardioselective, I recommend it. It has a longer half-life, too. My stress and panic response is a lot more reasonable now.

    • cheese_greater@lemmy.worldOP
      2·
      1 year ago

      To what extent does it address the mental aspect or does it do that indirectly on the meta level by making you less anxious because there is less physical anxiety to take notice of?

      Edit: I know lots of musicians in orchestras and other professional performers use them to steady hands etc

      • tsonfeir@lemm.ee
        3·
        1 year ago

        Part of anxiety is the physical effect of it. The tight chest, the elevated heart beat, the panic mode. It reduces that physical aspect so your brain can focus without FEELING like you’re under attack.

  • naevaTheRat@lemmy.dbzer0.com
    61·
    1 year ago

    Ketamine

    Fast acting relief from treatment resistant depression. Personally I find ~0.8 mg/kg subcutaneously injected is about the magic dose.

    After 20 odd years of living in a fog the first time I used that treatment was like night and day. I had forgotten how trivial most things are without depression. Exercise for example is just “I don’t wanna but I know I’ll feel better. Ugh fine” instead of something that takes about 3 days to psych up to on a good week.

    I find it’s very effective for about a week, dropping off over the next month or so. Unsure if lifetime sustainable at a frequency of ~2-3 weeks per dose but definitely useful to put in changes to life that make it easier to handle.

    Crazy expensive medically though, if you can get it tested infusions can be prepared diy (most is diverted from medical supply so it’s often not adultrated BUT NOT ALWAYS!) with bacteriostatic water and 0.22 um wheel filters. Obvs if you don’t know what you’re doing you could seriously harm yourself, and you absolutely must be able to secure safety measures like naloxone, but if the rope is looking mighty appealing it’s an option if you can’t get it medically.

    • Anamnesis@lemmy.world
      51·
      1 year ago

      It’s worth noting that in the US there are ketamine therapy companies that send you oral ketamine in the mail. It costs about $120 per month and is accessible after a short zoom appointment.

      • naevaTheRat@lemmy.dbzer0.com
        2·
        1 year ago

        I don’t know if it’s effective that way; all papers I’ve read that show affect are using nasal, IV, or subcutaneous.

        That said you should probs try that before risking infection and gaol if it’s an option. It’s about that much a dose in Australia (has to be administered under supervision) and requires extensive screening.

        • Anamnesis@lemmy.world
          21·
          1 year ago

          It’s definitely effective, but you have to take a higher dose vs. IV. Usually it’s between 60 and 120mg and it’s delivered via troche in the cheek.

          • naevaTheRat@lemmy.dbzer0.com
            3·
            1 year ago

            So that’s what ~1.5 mg/kg transdermal I guess. Assume some waste from swallowing. Yeah probably around the same delivery rate and dose as subcutaneous injection

  • charlytune@mander.xyz
    51·
    1 year ago

    Testosterone

    I’d tried a few different combinations of HRT (for menopause), and was doing ok ish on oestrogen patches and micronised progesterone capsules. But I still felt like a shadow of myself, a barely functioning husk.

    I ended up paying privately to see a menopause specialist (after finding out the waiting time for the NHS clinic I was referred to was at least a year and a half - just for my referral to get looked at), and she prescribed me testosterone. Within 48 hours I noticed a huge difference, I felt like I’d recovered a huge chunk of my energy and my personality.

    It makes me furious that it’s so hard to get. I’m not sure what state my mental health would be in if I hadn’t been able to get it. I was definitely looking at having to cut hours in work to be able to cope, and that would have had a big financial impact on me.

    And so many people I speak to - including women - are confused about why testosterone would help, there’s so much misunderstanding about hormones, they don’t know that women have testosterone and men have oestrogen. My aunt asked me whether it would reverse the menopause and I was just like er what… How would that even work?

  • FruitParty@lemmy.world
    4·
    1 year ago

    Yerba Mate

    Honestly, I think Yerba Mate is probably the most pleasant and cleanest caffeinated beverage around. I’ve pretty much entirely replaced coffee at this point, as Yerba Mate seems to have all around superior effects. The unique blend of methylxanthine stimulants present (caffeine, theobromine, theophylline) in Mate provides incredibly clean stimulation with no crash and little anxiety (for me anyway). It doesn’t make my stomach feel nasty after multiple cups, which I appreciate as well. The guayaki canned drinks initially got me into it, but I’ve since graduated to brewing the unsmoked loose leaf tea.

    • cheese_greater@lemmy.worldOP
      1·
      1 year ago

      What are the products to look for, brand-wise and things to look out for in terms of anything else to know when considering a product

      • FruitParty@lemmy.world
        3·
        1 year ago

        Personally, I prefer the unsmoked varieties of the loose leaf tea (although it is traditionally smoked). I do however prefer the traditional cut, which includes the stems and makes it less bitter. I get the “Eco Teas” brand, just because it seems to be available at one of the local, ritzy grocery stores. There are a million brands out there, I’ve only tried a few. Guayaki sells their loose leaf Mate at whole foods, but I have not tried it myself. I think the canned drinks are a good place to start to see if you like the effects, they just have a significant amount of sugar in them.

  • Nyssa Sylvatica@lemmy.worldEnglish
    41·
    1 year ago

    Escitalopram - Lexapro It took my anxiety from the point where I was having severe panic attacks for simple issues to where I was able to put down my problems.

    • Grayox@lemmy.ml
      3·
      1 year ago

      Lexapro has been amazing for me as well, went from smoking weed everyday to deal with my depression and stomach issues, to not even smoking anymore, coming up on a month pot free. Its crazy how much better you feel with the appropriate amount of serotonin in your system.

    • ellabee@sh.itjust.works
      2·
      1 year ago

      oh weird, Lexapro failed entirely at managing my anxiety. worked great on the depression side, which meant that dampener of the anxiety wasn’t in effect. spiraled quick, had to email the doc for an emergency appointment.

      Effexor (venlaxafine) is the first SNRI I’ve tried and it’s been like magic.

    • cheese_greater@lemmy.worldOP
      11·
      1 year ago

      Can you modify so its like

      Escitalopram (Lexapro)

      Body of text

      Thanks, it helps keep everything consistent and easily readable/comparable

  • cheese_greater@lemmy.worldOP
    21·
    1 year ago

    DXM/dextromethorphan (Robitussin Cough Gels)

    Its technically a dissociative and NMDA-antagonist, anaesthetic.

    DXM can be an amazing agent for inducing what I would term a hard reset, that is dissociating you the f-out to the extent you may be able to reevaluate and see things in a new light. You will need to take care it doesnt react with other ingested substances you take and there are different thresholds (plateaus) that purportedly have distinct characteristics.

    The best source is Robitussin Cough Gels, take care it is a single-ingredient product that you are considering trying. Have a pan to throw up in (you will vomit to some extent) and do not trust any farts.

    If you have urinary retention, take a super hot bath but be very careful, maybe have someone check in on you. The hot water will relax your muscles and basically force you to have to and be able to get it out. Limit liquid consumption before/during/after to avoid an unduly full bladder

    Edit: it might be a secret antidepressant akin to ketamine (similar profile) and the music euphoria is incredible

  • cheese_greater@lemmy.worldOP
    21·
    1 year ago

    Iron bisglycinate (supplement)

    Need an iron supplement but the regular ones (iron sulfate) plug your bowels up? You want iron bisglycinate.

    (Not author, will remove after original comment is properly formatted)