Xonsh. For basic use (running CLI programs with arguments) it works like any other shell, and for other uses it has nice Python syntax (and libraries!). For example, I like not needing a separate calculator program, as I can do maths directly in the shell with an intuitive syntax.
Andre Geim got the Ig Nobel for this. He is the only person this far to have got both the Ig Nobel and an actual Nobel prize.