Yeah that’s a really tough knot. My main point is that it’s rarely a miracle cure. But honestly you seem like you could use that 4-6hr recreationally 😁. I hope it helps you!
If it means anything i can relate in terms is the depression, anxiety, and burnout leading to pretty bad executive dysfunction and being convinced i had severe ADHD(undiagnosed, it’s mild if i have it). That was the last 5 years of my life. Moving to another country ended up being what enabled my ability to work on it.
The Nyquist limit?
You need sampling at twice the frequency as a minimum to extract a time domain signal into the frequency domain. It says nothing about “perfect” especially when you’re listening in the time domain.
There is a lot of data in the time domain that impacts sound/signal quality. As others have said though, it probably doesn’t matter without high quality equipment and a good ear.
It’s also good to note that you can train your hearing. A musician or producer or audiophile are going to hear things and qualities you don’t. It’s edge cases though, and generally irrelevant to regular listening.
You definitely can hear the difference between MP3 320 and lower mp3 bitrates though.