Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.
The publication itself, which seems to be legit, and well done.
Haven’t had a chance to read all of it, but it isn’t badly executed by a quick scan.
Edit: I’ve had a chance to read it in full.
About half of it is over my head. Just don’t have the biochemical background to be able to interpret much of the metabolites they were measuring.
That being said, that stuff isn’t actually important for casual interest.
Here’s the key points I found:
First, the study was mice only. While mice are excellent for this kind of work, you can’t guarantee things will be a 1:1 result in Holland p.
Second, the study was for low dose levels, and only delta-9 thc, with no other cannabinoids being used at all.
Third, the study was relatively short, with 42 days being the longer end.
Fourth, and this is the cool part, changes in the relevant metabolites and brain samples had benefit at the 14 day mark. So, if this does translate to human effects, short term, low dose use of delta-9 may be a valuable option. That’s years away before this could be confirmed as valid for humans, but the effects were significant.
All of that means that just smoking weed, you aren’t going to duplicate the conditions of the study. If you’re taking in enough to get high, you’re at a higher dose than the study, and that may cause an opposite effect long term.
This is a very focused experiment, with well defined limits and goals. The information gained can not be used as an indicator that smoking herb as an adult human will give any benefit, much less what is in the title of the article.
Think of this study as step one in maybe ten steps you get to the point where it would be useful for indicating benefits in humans, assuming everything went right along the way.
Maybe I’m misreading the only plot that mentions dosing numbers anywhere. It looks like the largest dosing group is getting 3mg/kg/day. That’s a lot scaled up to a 100kg person (like 10x a normal gummy for example).
It was three different doses, 0.3, 1, and 3 mg/kg per day
It was also delivered via subcutaneous pump, which is usually done with a mind towards a gradual dosing rather than a single push of the total amount all at once.
The kind of pump listed in the article previously linked was an osmotic pump.
Here’s an excerpt from a different paper describing the various methods for substance delivery:
Osmotic pumps are internally implanted devices that use an osmotic displacement system to infuse a preloaded substance into an animal. Use of these pumps permits constant dosing without the need to handle an animal after the initial implant surgery. Extracellular fluid is absorbed at a constant rate by an osmotic salt layer immediately beneath the permeable outer membrane. As the osmotic layer absorbs fluid, it swells and puts pressure on an impermeable reservoir in the center of the pump. The reservoir then expels the loaded substance from the pump at a constant rate through a flow moderator. The outflow can pass directly into the tissue surrounding the pump, or a cannula can be attached to the pump to direct the flow into a blood vessel or specific tissue.
Osmotic pumps are cylindrical in shape and come in sizes small enough for mice. These devices are surgically implanted either subcutaneously or intraperitoneally. The flow rate is fixed, and the duration of action varies from 3 d to 6 wk, depending on the size of the pump and the delivery rate selected. Pumps cannot be refilled but can be implanted sequentially to prolong dosing.
I’m not up on the dosing levels in humans, So I I don’t have the ability to know offhand if 3mg/kg spread over the day is unusually high (pun partially intended) or not. There’s a section I can’t find easily (I’m actually dyslexic so it takes me a while to get through this kind of dense and complicated writing) where they mentioned having a higher dose as a point of comparison.
Thanks this is a lot of great detail on the dosing mechanism that I think is really interesting. I love reading up on the experimental details and the actually components used to make these experiments work.
300mg of orally ingested THC spread out over 24 hours is about equivalent to consuming 1 typical candy/gummy every hour for 24 hours of the day. A reasonable or average or normal person would be uncomfortably high at these dosages. I also imagine the bioavailability of oral ingestion is less than the dosing mechanism you described although I’m not sure (is that getting taken up through the lymphatic system? How does it differ from oral ingestion or injection into the bloodstream?).
Fascinating stuff, thanks for sharing your knowledge.
Osmotic pumps tend to be equivalent to a transdermal patch in how the substance spreads through the body, but bypasses the need to go through skin. So, faster initially, but otherwise the dose over time would be the same, assuming the transdermal patch was able to maintain dosage (they aren’t, there’s a drop-off).
And, just as you said, the entire dose is taken in without any degradation by digestion, or being bound in something.
What I have zero clue about is what difference it would make in terms of numbers. It is equivalent in speed of uptake to subQ or IM injection, which is essentially immediate, just with a slight curve at the very beginning, so tiny it won’t be noticeable to someone that experienced all those deliveries.
Vs IV, the initial release is slower with osmotic pumps, but the sustain of the pumps makes everything after that different.
Basically, the pump goes under the skin and leaks the substance into the intracellular fluids, to be taken up by capillaries into the bloodstream.
I like hearing this so it must be true
Found the basis for CNN and Fox News retaining viewership!
It can also be true independent of one’s liking it.
That little aphorism you just trotted out is a thought terminating cliche, something that contributes nothing and artificially ends discussion.
You chose it deliberately to denigrate the study with zero evidence, and 11 people agreed with you.
Disturbing for lemmy.
It really isn’t any of that, they’re just humorously pointing out confirmation bias which is definitely an issue in discussions like these
You really don’t see how bad it’s gotten in just a year, do you?
I think you need to log off for your mental health
I think I’d rather trust the opinion of my degreed therapist than some rando on the internet, and even with my neurodivergences, she considers me to be a mentally fit and motivated individual.
There really should be a consequence for amateur psychology copypastas.
Mental health is not a binary state, you can have bad periods in an otherwise stable life. You’ve made a thousand posts in a month. I’m being completely genuine, I think you need to evaluate whether this is healthy for you.
Again, she’s got a degree, you likely don’t. I trust her judgment and it hasn’t been wrong in years. Please go bother someone else before I excise you from my internet experience forever.
You’ve made a thousand posts in a month. I
Bitch I have been posting on the internet since before it had pictures, and if you think a thousand posts in a month is significant, then you don’t want to hear about when I still had a reddit account.
Yes she knows, no she is not concerned and even considers it good therapy for me to practice handling my EDS, which I have to say has been a significant improvement in my quality of life. I mean just look at this post, I BARELY insulted you! 5 years ago that wouldn’t be the case and confronted with your rancid presence I would likely already be banned.
You are concern trolling and on any rational media platform that should be an instaban.
Idk, I’m high right now and my memory is shit.
Bro is doing PI work on the horny account.
What? Maybe your app is broken, those links are the same.
Or is it?
Short term vs long term
That’s what they mean by reversing brain aging
I started getting high later in life (25) and had shit memory beforehand.
It’s a bit less shit now, take that as you will.
Lmao benzinga the pinnacle of science news
There is a real study it’s referencing at least but these fucks are probably just trying to pump weed stocks
Same energy as “wine is good for you!” As it turns out, no. Wine is absolutely poisonous to you.
But taking 30 minutes out of your day to relax and unwind? That’s good for you.
It’s amazing to me that they misspelled “reaserch” in the first bullet item.
It’s turning back to the time before they knew how to spell
I’ve been stoned consistently since covid started. The only “sober” time is when I sleep. I don’t think younger, but most things don’t bother me. Want to improve your brain? Find consistent ways to reduce stress and perform them daily(like an hour walk outside). That will make you feel and think like a younger you.
No wonder Cheech&Chong, Willie Nelson, Snoop, and Lily Tomlin seem pretty young at heart/mind for their age
Well, I don’t know if we’ll be able to reverse brain aging anytime soon, but we at least know some ways of slowing it down, like by language learning or some other mental tasks.
I personally recommend at least giving a try for learning a new foreign language, it’s fascinating journey and even it might be hard at first it’s very satisfying in the end. And some people might say that it’s not worth it because of AI, but come on, you can still do it for fun, and bigger cultural understanding.
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I voted for this because I want it to be true. Yay, science!
never really expected so many prohibitionist shitbags on lemmy. Off to the blocklist you and your ilk go!
I wonder if micro dosing can give the same effects? I am a control freak and don’t like to be high but worry about cognitive decline. Especially since I got long covid and fucked up my olfactory system. Brain damage sucks.
Most days I microdose by diluting extract in glycerine, roughly 1/4 of a joint paced out thru the day.
Works wonders for my EDS, and I don’t feel high at all and have a ton more executive control.
Can’t really reply on the cognitive decline but I’m pushing 50 and still in the top .5%
Long Covid did drop me a bit tho, but I guess when you start with a straight eight, losing two cylinders isn’t so bad.
The actual paper published is about smaller doses.
It would be better to microdose lithium if you really don’t want to be high imo. 5-20mg range, can be intermittent (doses for bipolar are in the 100mg range and up). There’s already lithium in some water supplies and in foods like potatoes, so a small amount in a microdose normally doesn’t affect anyone negatively.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227915/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324565/
I will say over time your body will adjust to cannabis so if you microdose at night consistently before bed, you’ll just sleep it off anyway and eventually it won’t even get you high anymore.
When I was 17 I really turned back the clock. Almost every day we were reversing brain aging and boosting mental capacity.
There’s also this study from 2017, if you want more info on this.
I’m not convinced. Unless the idiot stoners in my area are so fucking stupid that even when you work some science magic to make them smarter, they are still about as intelligent as a sack of dirt.
Maybe it de-aged their brain too far?
