In trials
When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn’t working. So they began to just focus on one other, the Crohn’s, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.
I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.
Hope can be a dangerous thing. Hope can drive a man insane, as Red said.
Is it possible that other person was just full of shit?
Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:
Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.
Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.
The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.
This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.
And the press release talks about how they’ve moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.
A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP’s article), saying:
We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.
None of this looks like a company that has a failing drug on their hands. And there’s no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.
Being too ready to give up on hope is its own kind of insanity.
T1 diabetes here. A cure is just 5 years away…
They told me, when I was diagnosed in 1992.
Commercially viable fusion is always 20 yrs away so keep your chin up
Well damn, I got MS too but caught it fairly early. I’m hoping for a major breakthrough before it gets really bad.
I came for the Orange reference, but was not disappointed by Red.
Website I’ve never heard of: check
Wild claims that seem too good to be true: check
Little to no proof about said claims: check
Don’t get me wrong, this would be fantastic if it’s true. But I’m sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.
Here’s the article that should have been posted, except of course that it’s a few months old and nothing new has been reported on it yet that I know of. https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases
like the good ol r/science
this place is going doooown
I see it in google news all the time. spammy but I don’t see their ads. they gave references near the end.
Every science article is just a comment section disapproving the article. That’s why I stay away from these science communities, it’s all clickbait and lies
At the same time, commenters don’t necessarily know what the fuck they’re talking about either.
Yeah Reddit always had that problem, I think it’s here too - top rated comment is someone saying it won’t work and the article is wrong, everyone just accepts it without question.
I still see people using battery breakthrough stories as an example of stuff that never comes too market despite most of them being in the very phone the person is using.
I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it
I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it
So strange for those people to hang out in science communities in that case, to me.
a cat group I started the same time as this has 5k more subs and no whining. it is just cat pics. there are a lot of fake science sites to avoid but they all have bills to pay. they expect it to be like reddit junk and all. been to reddit through search results and sometimes found useful threads. mostly not.
Yeah, I think they come from the front page, I don’t think you see it as much on more obscure articles.
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What’s bad is that it’s a good article. It covers things very well
okay then
Only “ten more years to cure diabetes”
-Science 30 years ago
This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.
This is the most boomer shit and it is so sad to see people still saying it
In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.
That’s the way it reads, yes.
It would, if effective in human use, stop new damage, but not reverse existing damage.
I was wondering about that, curing Type 1 Diabetes would be a HELL of a breakthrough.
Curing it would lead to massive losses of a specific industry.
It really would. I fear that anything remotely close to a “cure” would be thwarted by pharma because they profit so much from insulin.
I switched jobs a few months ago, and had about 2 weeks without insurance. my insulin prescription was over $4k.
I know that “pharma” can’t just shut something down… but I’m sure there’s some loophole
Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏
Sounds pretty advanced. I bet they won’t be able to activate the mind control chips until 6G cell services launch.
I was under the impression that we were 5G access points with the covid vaccine?
Was I lied to? I thought I was doing a service to the fellow terminally online.
That’s a bold claim there, dennis
What about Hashimoto’s thyroiditis and Graves’ disease?
I remember seeing something on reddit about this earlier this year iirc. Definitely exciting and I certainly hope there is credence to this. Would love to see auto immune disorders go by the wayside in the next couple decades. Once they fix all the real bad ones I hope they make one for vitiligo, I’m tired of 70 spf sunblock and weird looking tans.
Is this the “T1D cure in 10 years” I was promised 21 years ago?
Allergies also?
What about alopecia?
i like how people complain because they weren’t properly spoon fed curated articles selected specifically for them by someone who gaf. 1) be kind - is a reminder to myself
This comment isn’t kind, it’s obnoxious.
thanks for the reminder
